British Journal of Sexual Medicine

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Anal cancer screening in men who have had sex with men
BJSM, Volume 31, Number 2.

Anal intraepithelial neoplasia (AIN) is a common condition in men who have had sex with men (MSM) and remain sexually active with multiple sexual partners, and this is true of all age groups. The EXPLORE study, conducted in four large cities in the USA, found a prevalence of high-grade (HG) AIN of 4–8% in HIV-negative MSM, the highest prevalence being in San Francisco. Strikingly, there was no reduction in prevalence with age, in contrast to cervical intraepithelial neoplasia (CIN) in women. The difference can largely be explained in terms of the average number of sexual partners being lower in heterosexuals.

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